Ellagic acid is a polyphenolic, non-flavonoid compound naturally stumbled on in a form of fruits, equivalent to pomegranates, raspberries, strawberries, and grapes, and nuts, equivalent to pistachios, pecans, walnuts, and acorns.
Senavirathna et al. are investigating the results ellagic acid — an antioxidant stumbled on in some pomegranates, raspberries, strawberries, and grapes, and nuts — will have on halting and doubtlessly reversing the wretchedness precipitated by fatty liver illness. Image credit rating: Engin Akyurt.
Obesity is in epidemic proportions in plenty of formulation of the arena, contributing to increasing charges of non-alcoholic fatty liver illness (NAFLD).
This swiftly-growing epidemic is mainly the most prevalent earn of power liver illness globally.
The prevalence of NAFLD has elevated from 25.24% in 2015 to 29.38% in 2021.
NAFLD represents a form of prerequisites from easy fatty liver (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH), which is in a living to progress to more excessive fibrosis etc.
There currently exists no medication for the long-duration of time administration of NAFLD/NASH, nonetheless, dietary interventions have been investigated for the medication of NASH, along side several polyphenolic compounds. Ellagic acid is one such compound.
“Ellagic acid, which is stumbled on in a form of meals equivalent to raspberries, pomegranate, blackberries, and pecan nuts, is widely acknowledged for its antioxidant properties, however furthermore displays anti-inflammatory, antifibrotic and anticancer properties,” acknowledged Edith Cowan University researcher Lois Balmer and PhD student Tharani Senavirathna.
“Ellagic acid stands out as a outstanding polyphenolic compound, possessing a huge sequence of pharmacological properties that retain promise in treating various power ailments, along side NAFLD.”
“Attributable to its multifaceted natural results, fit to be eaten vegetation containing ellagic acid, and its derivatives are recognised as priceless functional meals for making improvements to human successfully being.”
“Furthermore, there’s proof suggesting that ellagic acid, when blended with other antioxidant nutraceuticals, displays a synergistic therapeutic create, making it a potential candidate for mixture treatment.”
The authors have been occupied with a previously undertaken pilot discover investigating the results of several polyphenolic compounds on NAFLD, with ellagic acid exhibiting essentially the most promise in decreasing irritation.
“Ellagic acid exerts its hepatoprotective properties primarily through scavenging free radicals, modulating cytokine production, and regulating lipid metabolism,” they acknowledged.
“As an graceful antioxidant, ellagic acid acts in opposition to ROS and activates the NrF2 pathway to lower oxidative stress to guard the liver.”
“Remarkably, ellagic acid furthermore suppresses Nf-kB and MAPK pathways, mitigating irritation for the duration of NAFLD/NASH.”
“The proof furthermore shows that ellagic acid can lower each and each triglyceride and ldl cholesterol ranges, thus combating de novo lipogenesis, which is a vital possibility part in NASH progression.”
“In vitro, findings imply that ellagic acid has the potential to alleviate fibrosis.”
“The principle microbial metabolite for ellagic acid, urolithin, has been shown to toughen the intestine microbiome in several mouse objects of weight problems.”
“Specifically, urolithin A has been shown to lower LDL and enhance HDL ranges and is furthermore occupied with bettering lipid metabolism through gene regulation, while urolithin C activates the hepatic AMPK pathway, thus counteracting the pathophysiology of NAFLD.”
“There is an ongoing debate concerning the successfully being advantages of ellagic acid and urolithins for NAFLD/NASH, however there remains to be a lack of files concerning their natural create on the liver.”
“Given the involvement of lipid metabolism, oxidative stress, irritation, and insulin resistance within the pathogenesis of NASH, findings from this overview imply that ellagic acid could signify a potential meals intervention for NASH, no longer perfect to limit however doubtlessly reverse the pathological manifestations of NAFLD/NASH.”
The discover changed into printed within the journal Antioxidants.
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Tharani Senavirathna et al. 2024. Unlocking the Therapeutic Attainable of Ellagic Acid for Non-Alcoholic Fatty Liver Illness and Non-Alcoholic Steatohepatitis. Antioxidants 13 (4): 485; doi: 10.3390/antiox13040485
