Taking pictures and modeling mobile niches from dissociated single-cell and spatial info

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Printed: 02 April 2024

Nature Biotechnology

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Cells work alongside with their local atmosphere to total world tissue fair. By harnessing gene–gene covariation in mobile neighborhoods from spatial transcriptomics info, the covariance atmosphere (COVET) niche representation and the environmental variational inference (ENVI) info integration components mannequin phenotype–microenvironment interplay and reconstruct the spatial context of dissociated single-cell RNA sequencing datasets.

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Fig. 1: COVET represents the mobile niche for spatial analysis and for spatial inference of scRNA-seq info.

References

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Right here’s a summary of: Haviv, D. et al. The covariance atmosphere defines mobile niches for spatial inference. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02193-4 (2024)

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Taking pictures and modeling mobile niches from dissociated single-cell and spatial info.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02207-1

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